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Mouse Behavior From Autism Studies Not Reproducible


Today, we have an excellent example of why we should keep calm and carry on when it comes to mouse studies. At SFARI, a website for an autism research organization, Emily Singer writes that research groups cannot reproduce the reported “social deficit” behaviors in a mouse strain that’s intended to model autism in humans:

A 2008 study from Nils Brose’s lab at the Max Planck Institute in Göttingen, Germany, first suggested that mice lacking NLGN4 have a number of autism-like social deficits. The lab published similar findings from the mice in a paper in November.

But in September, two independent groups reported that the same strain of mice, bred from animals furnished by the Brose lab, do not show any social deficits.

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